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Christian Reich

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Background

Christian Reich is staff scientist at the Department of Medical informatics at Erasmus MC. He is a physician oncologist by training, received his bachelor’s degree in preclinical training from Humboldt University in Berlin and holds his M.D. and doctorate from the Medical University of Lübeck, Germany where he focused his research on T-cell activation and regulation. Christian has more than 20 years of experience in life science research and medicine and has worked at various positions in academia and industry on the development of computational methods and approaches to life science problems. He is Professor of Practice at Northeastern University. He is also Principal Investigator at the Observational Health Data Science and Informatics (OHDSI), which focuses on creating comprehensive evidence about disease, healthcare delivery and the effects of medical interventions through large-scale analysis of RWD. Prior to that he was a PI and Program Manager at the OMOP Program.

He was a practicing physician in Berlin and Ulm, Germany before moving to the European Bioinformatics Institute to work on the Human Genome Project. He then joined the biotech industry in 1998, where he worked in various positions on typical challenges in drug research and development, such as gene sequence and expression analysis, clinical trial design and analysis, systems biology, and outcome research, applying computational methods to large scale biological data. He held positions of Global Head of Discovery Informatics and Research and Development Information for Global Medicines Development North America at AstraZeneca. He went on to be VP Real World Solutions at IQVIA, leading a team of data scientists, software developers and informaticians to offer standardized analytics across a large global network of observational data.

 

Publications

  1. Lau WCY, Torre CO, Man KKC, Stewart HM, Seager S, Van Zandt M, Reich C, Li J, Brewster J, Lip GYH, Hingorani AD, Wei L, Wong ICK. Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study Ann Intern Med. 2022 Nov 1.
  2. Li X, Burn E, Duarte-Salles T, Yin C, Reich C, Delmestri A, Verhamme K, Rijnbeek P, Suchard MA, Li K, Mosseveld M, John LH, Mayer MA, Ramirez-Anguita JM, Cohet C, Strauss V, Prieto-Alhambra D. Comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with different covid-19 vaccines: international network cohort study from five European countries and the US BMJ. 2022 Oct 26;379:e071594.
  3. Lloyd PC, Hu M, Wong HL, Shoaibi A, Ke Zhou C, Lo AC, Amend K, Beachler DC, McMahill-Walraven CN, Smith ER, Seeger J, Secora A, Audrey Djibo D, Obidi J, Feng Y, Song J, Reich C, Harris C, Akhtar S, Clifford R, Selvam N, Pigoga JL, Jiao Y, Chillarige Y, MaCurdy T, Forshee R, Anderson SA. Near real-time surveillance of safety outcomes in US COVID-19 vaccine recipients aged 12 to 64 years Vaccine. 2022 Oct 26;40(45):6481-6488.
  4. Nishimura A, Xie J, Kostka K, Duarte-Salles T, Fernández Bertolín S, Aragón M, Blacketer C, Shoaibi A, DuVall SL, Lynch K, Matheny ME, Falconer T, Morales DR, Conover MM, Chan You S, Pratt N, Weaver J, Sena AG, Schuemie MJ, Reps J, Reich C, Rijnbeek PR, Ryan PB, Hripcsak G, Prieto-Alhambra D, Suchard MA. International cohort study indicates no association between alpha-1 blockers and susceptibility to COVID-19 in benign prostatic hyperplasia patients Front Pharmacol. 2022 Sep 14;13:945592.
  5. Abeysinghe R, Black A, Kaduk D, Li Y, Reich C, Davydov A, Yao L, Cui L. Towards quality improvement of vaccine concept mappings in the OMOP vocabulary with a semi-automated method J Biomed Inform. 2022 Oct;134:104162.
  6. Szarfman A, Levine JG, Tonning JM, Weichold F, Bloom JC, Soreth JM, Geanacopoulos M, Callahan L, Spotnitz M, Ryan Q, Pease-Fye M, Brownstein JS, Ed Hammond W, Reich C, Altman RB. Recommendations for achieving interoperable and shareable medical data in the USA Commun Med (Lond). 2022 Jul 18;2:86.
  7. Wong HL, Hu M, Zhou CK, Lloyd PC, Amend KL, Beachler DC, Secora A, McMahill-Walraven CN, Lu Y, Wu Y, Ogilvie RP, Reich C, Djibo DA, Wan Z, Seeger JD, Akhtar S, Jiao Y, Chillarige Y, Do R, Hornberger J, Obidi J, Forshee R, Shoaibi A, Anderson SA. Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases Lancet. 2022 Jun 11;399(10342):2191-2199.
  8. Kostka K, Duarte-Salles T, Prats-Uribe A, Sena AG, Pistillo A, Khalid S, Lai LYH, Golozar A, Alshammari TM, Dawoud DM, Nyberg F, Wilcox AB, Andryc A, Williams A, Ostropolets A, Areia C, Jung CY, Harle CA, Reich CG, Blacketer C, Morales DR, Dorr DA, Burn E, Roel E, Tan EH, Minty E, DeFalco F, de Maeztu G, Lipori G, Alghoul H, Zhu H, Thomas JA, Bian J, Park J, Martínez Roldán J, Posada JD, Banda JM, Horcajada JP, Kohler J, Shah K, Natarajan K, Lynch KE, Liu L, Schilling LM, Recalde M, Spotnitz M, Gong M, Matheny ME, Valveny N, Weiskopf NG, Shah N, Alser O, Casajust P, Park RW, Schuff R, Seager S, DuVall SL, You SC, Song S, Fernández-Bertolín S, Fortin S, Magoc T, Falconer T, Subbian V, Huser V, Ahmed WU, Carter W, Guan Y, Galvan Y, He X, Rijnbeek PR, Hripcsak G, Ryan PB, Suchard MA, Prieto-Alhambra D. Unraveling COVID-19: A Large-Scale Characterization of 4.5 Million COVID-19 Cases Using CHARYBDIS Clin Epidemiol. 2022 Mar 22;14:369-384.
  9. Lu Y, Van Zandt M, Liu Y, Li J, Wang X, Chen Y, Chen Z, Cho J, Dorajoo SR, Feng M, Hsu MH, Hsu JC, Iqbal U, Jonnagaddala J, Li YC, Liaw ST, Lim HS, Ngiam KY, Nguyen PA, Park RW, Pratt N, Reich C, Rhee SY, Sathappan SMK, Shin SJ, Tan HX, You SC, Zhang X, Krumholz HM, Suchard MA, Xu H. Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort JAMA Netw Open. 2022 Mar 1;5(3):e223877.
  10. Burn E, Li X, Kostka K, Stewart HM, Reich C, Seager S, Duarte-Salles T, Fernandez-Bertolin S, Aragón M, Reyes C, Martinez-Hernandez E, Marti E, Delmestri A, Verhamme K, Rijnbeek P, Horban S, Morales DR, Prieto-Alhambra D. Background rates of five thrombosis with thrombocytopenia syndromes of special interest for COVID-19 vaccine safety surveillance: Incidence between 2017 and 2019 and patient profiles from 38.6 million people in six European countries Pharmacoepidemiol Drug Saf. 2022 May;31(5):495-510.
  11. Williams RD, Markus AF, Yang C, Duarte-Salles T, DuVall SL, Falconer T, Jonnagaddala J, Kim C, Rho Y, Williams AE, Machado AA, An MH, Aragón M, Areia C, Burn E, Choi YH, Drakos I, Abrahão MTF, Fernández-Bertolín S, Hripcsak G, Kaas-Hansen BS, Kandukuri PL, Kors JA, Kostka K, Liaw ST, Lynch KE, Machnicki G, Matheny ME, Morales D, Nyberg F, Park RW, Prats-Uribe A, Pratt N, Rao G, Reich CG, Rivera M, Seinen T, Shoaibi A, Spotnitz ME, Steyerberg EW, Suchard MA, You SC, Zhang L, Zhou L, Ryan PB, Prieto-Alhambra D, Reps JM, Rijnbeek PR. Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network BMC Med Res Methodol. 2022 Jan 30;22(1):35.
  12. Morales DR, Ostropolets A, Lai L, Sena A, Duvall S, Suchard M, Verhamme K, Rjinbeek P, Posada J, Ahmed W, Alshammary T, Alghoul H, Alser O, Areia C, Blacketer C, Burn E, Casajust P, You SC, Dawoud D, Golozar A, Gong M, Jonnagaddala J, Lynch K, Matheny M, Minty E, Nyberg F, Uribe A, Recalde M, Reich C, Scheumie M, Shah K, Shah N, Schilling L, Vizcaya D, Zhang L, Hripcsak G, Ryan P, Prieto-Alhambra D, Durate-Salles T, Kostka K. Characteristics and outcomes of COVID-19 patients with and without asthma from the United States, South Korea, and Europe J Asthma. 2022 Feb 11:1-11.
  13. Reyes C, Pistillo A, Fernández-Bertolín S, Recalde M, Roel E, Puente D, Sena AG, Blacketer C, Lai L, Alshammari TM, Ahmed WU, Alser O, Alghoul H, Areia C, Dawoud D, Prats-Uribe A, Valveny N, de Maeztu G, Sorlí Redó L, Martinez Roldan J, Lopez Montesinos I, Schilling LM, Golozar A, Reich C, Posada JD, Shah N, You SC, Lynch KE, DuVall SL, Matheny ME, Nyberg F, Ostropolets A, Hripcsak G, Rijnbeek PR, Suchard MA, Ryan P, Kostka K, Duarte-Salles T. Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study BMJ Open. 2021 Dec 22;11(12):e057632.
  14. Nestsiarovich A, Reps JM, Matheny ME, DuVall SL, Lynch KE, Beaton M, Jiang X, Spotnitz M, Pfohl SR, Shah NH, Torre CO, Reich CG, Lee DY, Son SJ, You SC, Park RW, Ryan PB, Lambert CG. Predictors of diagnostic transition from major depressive disorder to bipolar disorder: a retrospective observational network study Transl Psychiatry. 2021 Dec 20;11(1):642.
  15. Reinecke I, Zoch M, Reich C, Sedlmayr M, Bathelt F. The Usage of OHDSI OMOP - A Scoping Review Stud Health Technol Inform. 2021 Sep 21;283:95-103.
  16. Chen R, Suchard MA, Krumholz HM, Schuemie MJ, Shea S, Duke J, Pratt N, Reich CG, Madigan D, You SC, Ryan PB, Hripcsak G. Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers: A Multinational Cohort Study Hypertension. 2021 Sep;78(3):591-603.
  17. Roel E, Pistillo A, Recalde M, Sena AG, Fernández-Bertolín S, Aragón M, Puente D, Ahmed WU, Alghoul H, Alser O, Alshammari TM, Areia C, Blacketer C, Carter W, Casajust P, Culhane AC, Dawoud D, DeFalco F, DuVall SL, Falconer T, Golozar A, Gong M, Hester L, Hripcsak G, Tan EH, Jeon H, Jonnagaddala J, Lai LYH, Lynch KE, Matheny ME, Morales DR, Natarajan K, Nyberg F, Ostropolets A, Posada JD, Prats-Uribe A, Reich CG, Rivera DR, Schilling LM, Soerjomataram I, Shah K, Shah NH, Shen Y, Spotniz M, Subbian V, Suchard MA, Trama A, Zhang L, Zhang Y, Ryan PB, Prieto-Alhambra D, Kostka K, Duarte-Salles T. Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain Cancer Epidemiol Biomarkers Prev. 2021 Oct;30(10):1884-1894.
  18. Recalde M, Roel E, Pistillo A, Sena AG, Prats-Uribe A, Ahmed WU, Alghoul H, Alshammari TM, Alser O, Areia C, Burn E, Casajust P, Dawoud D, DuVall SL, Falconer T, Fernández-Bertolín S, Golozar A, Gong M, Lai LYH, Lane JCE, Lynch KE, Matheny ME, Mehta PP, Morales DR, Natarjan K, Nyberg F, Posada JD, Reich CG, Rijnbeek PR, Schilling LM, Shah K, Shah NH, Subbian V, Zhang L, Zhu H, Ryan P, Prieto-Alhambra D, Kostka K, Duarte-Salles T. Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom Int J Obes (Lond). 2021 Nov;45(11):2347-2357.
  19. Duarte-Salles T, Vizcaya D, Pistillo A, Casajust P, Sena AG, Lai LYH, Prats-Uribe A, Ahmed WU, Alshammari TM, Alghoul H, Alser O, Burn E, You SC, Areia C, Blacketer C, DuVall S, Falconer T, Fernandez-Bertolin S, Fortin S, Golozar A, Gong M, Tan EH, Huser V, Iveli P, Morales DR, Nyberg F, Posada JD, Recalde M, Roel E, Schilling LM, Shah NH, Shah K, Suchard MA, Zhang L, Zhang Y, Williams AE, Reich CG, Hripcsak G, Rijnbeek P, Ryan P, Kostka K, Prieto-Alhambra D. Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience Pediatrics. 2021 Sep;148(3):e2020042929.
  20. Prats-Uribe A, Sena AG, Lai LYH, Ahmed WU, Alghoul H, Alser O, Alshammari TM, Areia C, Carter W, Casajust P, Dawoud D, Golozar A, Jonnagaddala J, Mehta PP, Gong M, Morales DR, Nyberg F, Posada JD, Recalde M, Roel E, Shah K, Shah NH, Schilling LM, Subbian V, Vizcaya D, Zhang L, Zhang Y, Zhu H, Liu L, Cho J, Lynch KE, Matheny ME, You SC, Rijnbeek PR, Hripcsak G, Lane JC, Burn E, Reich C, Suchard MA, Duarte-Salles T, Kostka K, Ryan PB, Prieto-Alhambra D. Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study BMJ. 2021 May 11;373:n1038.
  21. Ostropolets A, Reich C, Ryan P, Weng C, Molinaro A, DeFalco F, Jonnagaddala J, Liaw ST, Jeon H, Park RW, Spotnitz ME, Natarajan K, Argyriou G, Kostka K, Miller R, Williams A, Minty E, Posada J, Hripcsak G. Characterizing database granularity using SNOMED-CT hierarchy AMIA Annu Symp Proc. 2021 Jan 25;2020:983-992. eCollection 2020.
  22. Nishimura A, Xie J, Kostka K, Duarte-Salles T, Bertolín SF, Aragón M, Blacketer C, Shoaibi A, DuVall SL, Lynch K, Matheny ME, Falconer T, Morales DR, Conover MM, You SC, Pratt N, Weaver J, Sena AG, Schuemie MJ, Reps J, Reich C, Rijnbeek PR, Ryan PB, Hripcsak G, Prieto-Alhambra D, Suchard MA. Alpha-1 blockers and susceptibility to COVID-19 in benign prostate hyperplasia patients : an international cohort study medRxiv. 2021 Mar 24:2021.03.18.21253778.
  23. Chan You S, Krumholz HM, Suchard MA, Schuemie MJ, Hripcsak G, Chen R, Shea S, Duke J, Pratt N, Reich CG, Madigan D, Ryan PB, Woong Park R, Park S. Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study Hypertension. 2021 May 5;77(5):1528-1538.
  24. Tan EH, Sena AG, Prats-Uribe A, You SC, Ahmed WU, Kostka K, Reich C, Duvall SL, Lynch KE, Matheny ME, Duarte-Salles T, Bertolin SF, Hripcsak G, Natarajan K, Falconer T, Spotnitz M, Ostropolets A, Blacketer C, Alshammari TM, Alghoul H, Alser O, Lane JCE, Dawoud DM, Shah K, Yang Y, Zhang L, Areia C, Golozar A, Recalde M, Casajust P, Jonnagaddala J, Subbian V, Vizcaya D, Lai LYH, Nyberg F, Morales DR, Posada JD, Shah NH, Gong M, Vivekanantham A, Abend A, Minty EP, Suchard M, Rijnbeek P, Ryan PB, Prieto-Alhambra D. COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries Rheumatology (Oxford). 2021 Oct 9;60(SI):SI37-SI50.
  25. Prieto-Alhambra D, Kostka K, Duarte-Salles T, Prats-Uribe A, Sena A, Pistillo A, Khalid S, Lai L, Golozar A, Alshammari TM, Dawoud D, Nyberg F, Wilcox A, Andryc A, Williams A, Ostropolets A, Areia C, Jung CY, Harle C, Reich C, Blacketer C, Morales D, Dorr DA, Burn E, Roel E, Tan EH, Minty E, DeFalco F, de Maeztu G, Lipori G, Alghoul H, Zhu H, Thomas J, Bian J, Park J, Roldán JM, Posada J, Banda JM, Horcajada JP, Kohler J, Shah K, Natarajan K, Lynch K, Liu L, Schilling L, Recalde M, Spotnitz M, Gong M, Matheny M, Valveny N, Weiskopf N, Shah N, Alser O, Casajust P, Park RW, Schuff R, Seager S, DuVall S, You SC, Song S, Fernández-Bertolín S, Fortin S, Magoc T, Falconer T, Subbian V, Huser V, Ahmed WU, Carter W, Guan Y, Galvan Y, He X, Rijnbeek P, Hripcsak G, Ryan P, Suchard M. Unraveling COVID-19: a large-scale characterization of 4.5 million COVID-19 cases using CHARYBDIS Res Sq. 2021 Mar 1:rs.3.rs-279400.
  26. Reps JM, Kim C, Williams RD, Markus AF, Yang C, Duarte-Salles T, Falconer T, Jonnagaddala J, Williams A, Fernández-Bertolín S, DuVall SL, Kostka K, Rao G, Shoaibi A, Ostropolets A, Spotnitz ME, Zhang L, Casajust P, Steyerberg EW, Nyberg F, Kaas-Hansen BS, Choi YH, Morales D, Liaw ST, Abrahão MTF, Areia C, Matheny ME, Lynch KE, Aragón M, Park RW, Hripcsak G, Reich CG, Suchard MA, You SC, Ryan PB, Prieto-Alhambra D, Rijnbeek PR. Implementation of the COVID-19 Vulnerability Index Across an International Network of Health Care Data Sets: Collaborative External Validation Study JMIR Med Inform. 2021 Apr 5;9(4):e21547.
  27. Seong Y, You SC, Ostropolets A, Rho Y, Park J, Cho J, Dymshyts D, Reich CG, Heo Y, Park RW. Incorporation of Korean Electronic Data Interchange Vocabulary into Observational Medical Outcomes Partnership Vocabulary Healthc Inform Res. 2021 Jan;27(1):29-38.
  28. Belenkaya R, Gurley MJ, Golozar A, Dymshyts D, Miller RT, Williams AE, Ratwani S, Siapos A, Korsik V, Warner J, Campbell WS, Rivera D, Banokina T, Modina E, Bethusamy S, Stewart HM, Patel M, Chen R, Falconer T, Park RW, You SC, Jeon H, Shin SJ, Reich C. Extending the OMOP Common Data Model and Standardized Vocabularies to Support Observational Cancer Research JCO Clin Cancer Inform. 2021 Jan;5:12-20.
  29. Lane JCE, Weaver J, Kostka K, Duarte-Salles T, Abrahao MTF, Alghoul H, Alser O, Alshammari TM, Areia C, Biedermann P, Banda JM, Burn E, Casajust P, Fister K, Hardin J, Hester L, Hripcsak G, Kaas-Hansen BS, Khosla S, Kolovos S, Lynch KE, Makadia R, Mehta PP, Morales DR, Morgan-Stewart H, Mosseveld M, Newby D, Nyberg F, Ostropolets A, Woong Park R, Prats-Uribe A, Rao GA, Reich C, Rijnbeek P, Sena AG, Shoaibi A, Spotnitz M, Subbian V, Suchard MA, Vizcaya D, Wen H, Wilde M, Xie J, You SC, Zhang L, Lovestone S, Ryan P, Prieto-Alhambra D; OHDSI-COVID-19 consortium. Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study Rheumatology (Oxford). 2021 Jul 1;60(7):3222-3234.
  30. Jin S, Kostka K, Posada JD, Kim Y, Seo SI, Lee DY, Shah NH, Roh S, Lim YH, Chae SG, Jin U, Son SJ, Reich C, Rijnbeek PR, Park RW, You SC. Prediction of Major Depressive Disorder Following Beta-Blocker Therapy in Patients with Cardiovascular Diseases J Pers Med. 2020 Dec 18;10(4):288.
  31. Burn E, Sena AG, Prats-Uribe A, Spotnitz M, DuVall S, Lynch KE, Matheny ME, Nyberg F, Ahmed WU, Alser O, Alghoul H, Alshammari T, Zhang L, Casajust P, Areia C, Shah K, Reich C, Blacketer C, Andryc A, Fortin S, Natarajan K, Gong M, Golozar A, Morales D, Rijnbeek P, Subbian V, Roel E, Recalde M, Lane JCE, Vizcaya D, Posada JD, Shah NH, Jonnagaddala J, Lai LYH, Avilés-Jurado FX, Hripcsak G, Suchard MA, Ranzani OT, Ryan P, Prieto-Alhambra D, Kostka K, Duarte-Salles T. Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 842,928 patients hospitalized with COVID-19 in the United States medRxiv. 2021 Feb 12:2020.11.25.20229088.
  32. Tan EH, Sena AG, Prats-Uribe A, You SC, Ahmed WU, Kostka K, Reich C, Duvall SL, Lynch KE, Matheny ME, Duarte-Salles T, Bertolin SF, Hripcsak G, Natarajan K, Falconer T, Spotnitz M, Ostropolets A, Blacketer C, Alshammari TM, Alghoul H, Alser O, Lane JCE, Dawoud DM, Shah K, Yang Y, Zhang L, Areia C, Golozar A, Relcade M, Casajust P, Jonnagaddala J, Subbian V, Vizcaya D, Lai LY, Nyberg F, Morales DR, Posada JD, Shah NH, Gong M, Vivekanantham A, Abend A, Minty EP, Suchard M, Rijnbeek P, Ryan PB, Prieto-Alhambra D. Characteristics, outcomes, and mortality amongst 133,589 patients with prevalent autoimmune diseases diagnosed with, and 48,418 hospitalised for COVID-19: a multinational distributed network cohort analysis medRxiv. 2020 Nov 27:2020.11.24.20236802.
  33. Duarte-Salles T, Vizcaya D, Pistillo A, Casajust P, Sena AG, Lai LYH, Prats-Uribe A, Ahmed WU, Alshammari TM, Alghoul H, Alser O, Burn E, You SC, Areia C, Blacketer C, DuVall S, Falconer T, Fernandez-Bertolin S, Fortin S, Golozar A, Gong M, Tan EH, Huser V, Iveli P, Morales DR, Nyberg F, Posada JD, Recalde M, Roel E, Schilling LM, Shah NH, Shah K, Suchard MA, Zhang L, Zhang Y, Williams AE, Reich CG, Hripcsak G, Rijnbeek P, Ryan P, Kostka K, Prieto-Alhambra D. Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study medRxiv. 2020 Oct 30:2020.10.29.20222083.
  34. Golozar A, Lai LY, Sena AG, Vizcaya D, Schilling LM, Huser V, Nyberg F, Duvall SL, Morales DR, Alshammari TM, Abedtash H, Ahmed WU, Alser O, Alghoul H, Zhang Y, Gong M, Guan Y, Areia C, Jonnagaddala J, Shah K, Lane JCE, Prats-Uribe A, Posada JD, Shah NH, Subbian V, Zhang L, Fernandes Abrahão MT, Rijnbeek PR, You SC, Casajust P, Roel E, Recalde M, Fernández-Bertolín S, Andryc A, Thomas JA, Wilcox AB, Fortin S, Blacketer C, DeFalco F, Natarajan K, Falconer T, Spotnitz M, Ostropolets A, Hripcsak G, Suchard M, Lynch KE, Matheny ME, Williams A, Reich C, Duarte-Salles T, Kostka K, Ryan PB, Prieto-Alhambra D. Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States medRxiv. 2020 Oct 27:2020.10.25.20218875.
  35. You SC, Rho Y, Bikdeli B, Kim J, Siapos A, Weaver J, Londhe A, Cho J, Park J, Schuemie M, Suchard MA, Madigan D, Hripcsak G, Gupta A, Reich CG, Ryan PB, Park RW, Krumholz HM. Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention JAMA. 2020 Oct 27;324(16):1640-1650.
  36. Burn E, You SC, Sena AG, Kostka K, Abedtash H, Abrahão MTF, Alberga A, Alghoul H, Alser O, Alshammari TM, Aragon M, Areia C, Banda JM, Cho J, Culhane AC, Davydov A, DeFalco FJ, Duarte-Salles T, DuVall S, Falconer T, Fernandez-Bertolin S, Gao W, Golozar A, Hardin J, Hripcsak G, Huser V, Jeon H, Jing Y, Jung CY, Kaas-Hansen BS, Kaduk D, Kent S, Kim Y, Kolovos S, Lane JCE, Lee H, Lynch KE, Makadia R, Matheny ME, Mehta PP, Morales DR, Natarajan K, Nyberg F, Ostropolets A, Park RW, Park J, Posada JD, Prats-Uribe A, Rao G, Reich C, Rho Y, Rijnbeek P, Schilling LM, Schuemie M, Shah NH, Shoaibi A, Song S, Spotnitz M, Suchard MA, Swerdel JN, Vizcaya D, Volpe S, Wen H, Williams AE, Yimer BB, Zhang L, Zhuk O, Prieto-Alhambra D, Ryan P. Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study Nat Commun. 2020 Oct 6;11(1):5009.
  37. Lane JCE, Weaver J, Kostka K, Duarte-Salles T, Abrahao MTF, Alghoul H, Alser O, Alshammari TM, Biedermann P, Banda JM, Burn E, Casajust P, Conover MM, Culhane AC, Davydov A, DuVall SL, Dymshyts D, Fernandez-Bertolin S, Fišter K, Hardin J, Hester L, Hripcsak G, Kaas-Hansen BS, Kent S, Khosla S, Kolovos S, Lambert CG, van der Lei J, Lynch KE, Makadia R, Margulis AV, Matheny ME, Mehta P, Morales DR, Morgan-Stewart H, Mosseveld M, Newby D, Nyberg F, Ostropolets A, Park RW, Prats-Uribe A, Rao GA, Reich C, Reps J, Rijnbeek P, Sathappan SMK, Schuemie M, Seager S, Sena AG, Shoaibi A, Spotnitz M, Suchard MA, Torre CO, Vizcaya D, Wen H, de Wilde M, Xie J, You SC, Zhang L, Zhuk O, Ryan P, Prieto-Alhambra D; OHDSI-COVID-19 consortium. Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study Lancet Rheumatol. 2020 Nov;2(11):e698-e711.
  38. Kim Y, Tian Y, Yang J, Huser V, Jin P, Lambert CG, Park H, You SC, Park RW, Rijnbeek PR, Van Zandt M, Reich C, Vashisht R, Wu Y, Duke J, Hripcsak G, Madigan D, Shah NH, Ryan PB, Schuemie MJ, Suchard MA. Comparative safety and effectiveness of alendronate versus raloxifene in women with osteoporosis Sci Rep. 2020 Jul 6;10(1):11115.
  39. Omar MI, Roobol MJ, Ribal MJ, Abbott T, Agapow PM, Araujo S, Asiimwe A, Auffray C, Balaur I, Beyer K, Bernini C, Bjartell A, Briganti A, Butler-Ransohoff JE, Campi R, Cavelaars M, De Meulder B, Devecseri Z, Voss MD, Dimitropoulos K, Evans-Axelsson S, Franks B, Fullwood L, Horgan D, Smith EJ, Kiran A, Kivinummi K, Lambrecht M, Lancet D, Lindgren P, MacLennan S, MacLennan S, Nogueira MM, Moen F, Moinat M, Papineni K, Reich C, Reiche K, Rogiers S, Sartini C, van Bochove K, van Diggelen F, Van Hemelrijck M, Van Poppel H, Zong J, N'Dow J; PIONEER Consortium. Author Correction: Introducing PIONEER: a project to harness big data in prostate cancer research Nat Rev Urol. 2020 Aug;17(8):482.
  40. Burn E, You SC, Sena A, Kostka K, Abedtash H, Abrahao MTF, Alberga A, Alghoul H, Alser O, Alshammari TM, Aragon M, Areia C, Banda JM, Cho J, Culhane AC, Davydov A, DeFalco FJ, Duarte-Salles T, DuVall SL, Falconer T, Fernandez-Bertolin S, Gao W, Golozar A, Hardin J, Hripcsak G, Huser V, Jeon H, Jing Y, Jung CY, Kaas-Hansen BS, Kaduk D, Kent S, Kim Y, Kolovos S, Lane J, Lee H, Lynch KE, Makadia R, Matheny ME, Mehta P, Morales DR, Natarajan K, Nyberg F, Ostropolets A, Park RW, Park J, Posada JD, Prats-Uribe A, Rao GA, Reich C, Rho Y, Rijnbeek P, Schilling LM, Schuemie M, Shah NH, Shoaibi A, Song S, Spotnitz M, Suchard MA, Swerdel J, Vizcaya D, Volpe S, Wen H, Williams AE, Yimer BB, Zhang L, Zhuk O, Prieto-Alhambra D, Ryan P. Deep phenotyping of 34,128 patients hospitalised with COVID-19 and a comparison with 81,596 influenza patients in America, Europe and Asia: an international network study. medRxiv. 2020 Jun 28:2020.04.22.20074336.
  41. Omar MI, Roobol MJ, Ribal MJ, Abbott T, Agapow PM, Araujo S, Asiimwe A, Auffray C, Balaur I, Beyer K, Bernini C, Bjartell A, Briganti A, Butler-Ransohoff JE, Campi R, Cavelaars M, De Meulder B, Devecseri Z, Voss MD, Dimitropoulos K, Evans-Axelsson S, Franks B, Fullwood L, Horgan D, Smith EJ, Kiran A, Kivinummi K, Lambrecht M, Lancet D, Lindgren P, MacLennan S, MacLennan S, Nogueira MM, Moen F, Moinat M, Papineni K, Reich C, Reiche K, Rogiers S, Sartini C, van Bochove K, van Diggelen F, Van Hemelrijck M, Van Poppel H, Zong J, N'Dow J; PIONEER Consortium. Introducing PIONEER: a project to harness big data in prostate cancer research Nat Rev Urol. 2020 Jun;17(6):351-362.
  42. Bianco Z, Bukoski A, Masseau I, Reich C, Schultz L, Reinero C. Risk Factors and Outcomes in Dogs With Respiratory Disease Undergoing Diagnostic Airway Lavage Front Vet Sci. 2020 Apr 17;7:165.
  43. Chen R, Ryan P, Natarajan K, Falconer T, Crew KD, Reich CG, Vashisht R, Randhawa G, Shah NH, Hripcsak G. Treatment Patterns for Chronic Comorbid Conditions in Patients With Cancer Using a Large-Scale Observational Data Network JCO Clin Cancer Inform. 2020 Mar;4:171-183.
  44. Wang  Q, Reps  JM, Kostka  KF, Ryan  PB, Zou  Y, Voss  EA, Rijnbeek  PR, Chen  R, Rao  GA, Stewart  HM, Williams  AE, Williams  RD, van Zandt  M, Falconer  T, Fernandez-Chas  M, Vashisht  R, Pfohl  SR, Shah  NH, Kasthurirathne  SN, You  SC, Jiang  Q, Reich C, Zhou Y: Development and validation of a prognostic model predicting symptomatic hemorrhagic transformation in acute ischemic stroke at scale in the OHDSI network. PLoS ONE 2020 15(1)
  45. Suchard MA, Schuemie MJ, Krumholz HM, You SC, Chen RJ, Pratt N, Reich CG, Duke J, Madigan D, Hripcsak G, Ryan PB: Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis. Lancet. 2019 Nov 16;394(10211):1816-1826.
  46. Belenkaya R, Gurley M, Dymshyts D, Araujo S, Williams A, Chen R, Reich C. Standardized Observational Cancer Research Using the OMOP CDM Oncology Module. Stud Health Technol Inform. 2019 Aug 21;264:1831-1832.
  47. Warner JL, Dymshyts D, Reich CG, Gurley MJ, Hochheiser H, Moldwin ZH, Belenkaya R, Williams AE, Yang PC. HemOnc: A New Standard Vocabulary for Chemotherapy Regimen Representation in the OMOP Common Data Model. J Biomed Inform. 2019 Jun 22:103239.
  48. Vashisht R, Jung K, Schuler A, Banda JM, Park RW, Jin S, Li L, Dudley JT, Johnson KW, Shervey MM, Xu H, Wu Y, Natrajan K, Hripcsak G, Jin P, Van Zandt M, Reckard A, Reich CG, Weaver J, Schuemie MJ, Ryan PB, Callahan A, Shah NH. Association of Hemoglobin A1c Levels With Use of Sulfonylureas, Dipeptidyl Peptidase 4 Inhibitors, and Thiazolidinediones in Patients With Type 2 Diabetes Treated With Metformin: Analysis From the Observational Health Data Sciences and Informatics Initiative. JAMA Netw Open. 2018 Aug 3;1(4):e181755
  49. Schuemie MJ, Madigan D, Ryan PB, Reich C, Suchard MA, Berlin JA, Hripcsak G. Comment on "How pharmacoepidemiology networks can manage distributed analyses to improve replicability and transparency and minimize bias". Pharmacoepidemiol Drug Saf. 2019 Jul;28(7):1032-1033.
  50. Shin SJ, You SC, Park YR, Roh J, Kim JH, Haam S, Reich CG, Blacketer C, Son DS, Oh S, Park RW. Genomic Common Data Model for Seamless Interoperation of Biomedical Data in Clinical Practice: Retrospective Study. J Med Internet Res. 2019 Mar 26;21(3):e13249.
  51. Galaznik A, Reich C, Klebanov G, Khoma Y, Allakhverdiiev E, Hather G, Shou Y. Predicting Outcomes in Patients With Diffuse Large B-Cell Lymphoma Treated With Standard of Care. Cancer Inform. 2019 Mar 15;18:1176935119835538.
  52. Vashisht R, Jung K, Schuler A, Banda JM, Park RW, Jin S, Li L, Dudley JT, Johnson KW, Shervey MM, Xu H, Wu Y, Natrajan K, Hripcsak G, Jin P, Van Zandt M, Reckard A, Reich CG, Weaver J, Schuemie MJ, Ryan PB, Callahan A, Shah NH. Association of Hemoglobin A1c Levels With Use of Sulfonylureas, Dipeptidyl Peptidase 4 Inhibitors, and Thiazolidinediones in Patients With Type 2 Diabetes Treated With Metformin: Analysis From the Observational Health Data Sciences and Informatics Initiative. JAMA Netw Open. 2018 Aug 3;1(4):e181755.
  53. Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, Ma'ayan A, Malovannaya A, Mani S, Mathias SL, McManus MT, Meehan TF, von Mering C, Muthas D, Nguyen DT, Overington JP, Papadatos G, Qin J, Reich C, Roth BL, Schürer SC, Simeonov A, Sklar LA, Southall N, Tomita S, Tudose I, Ursu O, Vidovic D, Waller A, Westergaard D, Yang JJ, Zahoránszky-Köhalmi G. Unexplored therapeutic opportunities in the human genome. Nat Rev Drug Discov. 2018 Feb 23.
  54. Duke JD, Ryan PB, Suchard MA, Hripcsak G, Jin P, Reich C, Schwalm MS, Khoma Y, Wu Y, Xu H, Shah NH, Banda JM, J Schuemie M. Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data  sciences and informatics research network. Epilepsia. 2017 Aug;58(8):e101-e106.
  55. Boyce RD, Voss EA, Huser V, Evans L, Reich C, Duke JD, Tatonetti NP, Lorberbaum T, Dumontier M, Hauben M, Wallberg M, Peng L, Dempster S, He Y, Sena AG, Koutkias V, Natsiavas P, Ryan PB. Knowledge Base workgroup of the Observational Health Data Sciences and Informatics (OHDSI) collaborative. Large-scale adverse effects related to treatment evidence standardization (LAERTES): an open scalable system for linking pharmacovigilance evidence sources with clinical data. J Biomed Semantics. 2017 Mar 7;8(1):11.
  56. Hripcsak G, Ryan PB, Duke JD, Shah NH, Park RW, Huser V, Suchard MA, Schuemie  MJ, DeFalco FJ, Perotte A, Banda JM, Reich CG, Schilling LM, Matheny ME, Meeker D, Pratt N, Madigan D. Characterizing treatment pathways at scale using the OHDSI network. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7329-36.
  57. Gruber S, Chakravarty A, Heckbert SR, Levenson M, Martin D, Nelson JC, Psaty BM, Pinheiro S, Reich CG, Toh S, Walker AM. Design and analysis choices for safety surveillance evaluations need to be tuned to the specifics of the hypothesized drug-outcome association. Pharmacoepidemiol Drug Saf. 2016 Jul 14.
  58. Hripcsak G, Ryan PB, Duke JD, Shah NH, Park RW, Huser V, Suchard MA, Schuemie MJ, DeFalco FJ, Perotte A, Banda JM, Reich CG, Schilling LM, Matheny ME, Meeker D, Pratt N, Madigan D. Characterizing treatment pathways at scale using the OHDSI network. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7329-36.
  59. Hripcsak G, Duke JD, Shah NH, Reich CG, Huser V, Schuemie MJ, Suchard MA, Park RW, Wong IC, Rijnbeek PR, van der Lei J, Pratt N, Norén GN, Li YC, Stang PE, Madigan D, Ryan PB. Observational Health Data Sciences and Informatics (OHDSI): Opportunities for Observational Researchers. Stud Health Technol Inform. 2015;216:574-8.
  60. Bell C, Chakravarty A, Gruber S, Heckbert SR, Levenson M, Martin D, Nelson JC, Pinheiro S, Psaty BM, Reich CG, Schneeweiss S, Shoaibi A, Toh S, Walker AM. Characteristics of study design and elements that may contribute to the success of electronic safety monitoring systems. Pharmacoepidemiol Drug Saf. 2014 Nov;23(11):1223-5.
  61. Matcho A, Ryan P, Fife D, Reich C. Fidelity assessment of a clinical practice research datalink conversion to the OMOP common data model. Drug Saf. 2014 Nov;37(11):945-59.
  62. Boyce RD, Ryan PB, Norén GN, Schuemie MJ, Reich C, Duke J, Tatonetti NP, Trifirò G, Harpaz R, Overhage JM, Hartzema AG, Khayter M, Voss EA, Lambert CG, Huser V, Dumontier M. Bridging Islands of Information to Establish an Integrated Knowledge Base of Drugs and Health Outcomes of Interest. Drug Saf. 2014 Jul 2.
  63. Reich CG, Ryan PB, Suchard MA. The impact of drug and outcome prevalence on the feasibility and performance of analytical methods for a risk identification and analysis system. Drug Saf. 2013 Oct;36 Suppl 1:S195-204.
  64. Reich CG, Ryan PB, Schuemie MJ. Alternative outcome definitions and their effect on the performance of methods for observational outcome studies. Drug Saf. 2013 Oct;36 Suppl 1:S181-93.
  65. Ryan PB, Stang PE, Overhage JM, Suchard MA, Hartzema AG, DuMouchel W, Reich CG, Schuemie MJ, Madigan D. A comparison of the empirical performance of methods for a risk identification system. Drug Saf. 2013 Oct;36 Suppl 1:S143-58.
  66. Hartzema AG, Reich CG, Ryan PB, Stang PE, Madigan D, Welebob E, Overhage JM. Managing data quality for a drug safety surveillance system. Drug Saf. 2013 Oct;36 Suppl 1:S49-58.
  67. Reich C, Ryan PB, Stang PE, Rocca M. Evaluation of alternative standardized terminologies for medical conditions within a network of observational healthcare databases. Journal of Biomedical Informatics 2012; 45: 689-696.
  68. Overhage JM, Ryan PB, Reich CG et al. Validation of a common data model for active safety surveillance research. J Am Med Inform Assoc. 2012;19(1):54-60. Epub 2011 Oct 28
  69. Overhage JM, Ryan PB, Reich CG, et al. Validation of a common data model for active safety surveillance research. J Am Med Inform Assoc (2011). doi:10.1136/amiajnl-2011-000376.
  70. Stang PE, Ryan PB, Dusetzina SB, Hartzema AG, Reich C, Overhage JM, & Racoosin JA. Health Outcomes of Interest in Observational Data: Issues in Identifying Definitions in the Literature. Health Outcomes Research in Medicine (2011)
  71. Stang PE, Ryan PB, Racoosin JA, Overhage JM, Hartzema AG, Reich C, et al. Advancing the science for active surveillance: rationale and design for the Observational Medical Outcomes Partnership. Ann Intern Med. 2010 Nov 2;153(9):600-6
  72. Mattern T, Reich C, Schönbeck U, Ansorge S, Demuth HU, Loppnow H, Ulmer AJ, Flad HD. CD26 (Dipeptidyl Peptidase IV) does not contribute to adhesion of T cells to Endothelial Cells, Fibroblasts or extracellular matrix. Immunobiology, 1998; 198:465-75.
  73. Reich C, Ulmer AJ, Flad HD, Schönbeck U, Ansorge S, Demuth HU, and Mattern T. Does CD26 (dipeptidyl peptidase IV) contribute to adhesion of T cells to endothelial cells, fibroblasts or extracellular matrix?”; Leucocyte Typing V , White Cell Differentiation Antigens, Oxford University Press, Oxford, 1995; 1109-1111
  74. Mattern T, Reich C, Duchrow M, Ansorge S, Ulmer AJ, Flad HD. Antibody-induced modulation of CD26 surface expression. Immunology 1995; 84: 595-600
  75. Mattern T, Reich C, Ansorge S, Flad HD, and Ulmer AJ. Antibodies against CD26 induce modulation of CD26 expression on the surface of human T-lymphocytes. Eur.J.Cell Biol. 1994; 63, Suppl. 40: 22
  76. Mattern T, Reich C, Ansorge S, Ulmer AJ, and Flad HD. Modulation of CD26 surface expression by anti-CD26 monoclonal antibodies. Tissue Antigens. 1993 42: 249