Background

Marcel graduated as a software engineer in 1997. He did two internships at the Erasmus Medical Center and continued working there at the department of Medical Informatics.

His main responsibility is the Integrated Primary Care Information (IPCI) database, a research database containing patient data from over 700 Dutch general practitioners. This work includes the development of ETL processes for 10 different vendors, data profiling, data quality control, preparing the raw data for research and advising the researchers.

In OHDSI and the European Health Data and Evidence Network (EHDEN, www.ehden.eu) project he is contributing to the design and development of tools for ETL and database profiling.

His main interests are ETL, data profiling, data visualization and data quality.

Publications

• Patterns of knee osteoarthritis management in general practice: a retrospective cohort study using electronic health records
  Arslan, Ilgin & Berkel, A. & Damen, Jurgen & Bindels, Patrick & Wilde, M. & Bierma-Zeinstra, S. & Schiphof, Dieuwke. (2024). BMC Primary Care. 25. 10.1186/s12875-023-02198-z.

• Descriptive analysis on disproportionate medication errors and associated patient characteristics in the Food and Drug Administration's Adverse Event Reporting System
  Victor Pera, Frauke van Vaerenbergh, Jan A. Kors, Erik M. van Mulligen, Rowan Parry, Marcel de Wilde, Lies Lahousse, Johan van der Lei, Peter R. Rijnbeek, Katia M. C. Verhamme. 29 December 2023 https://doi.org/10.1002/pds.5743

• Parasitic infections related to anti-type 2 immunity monoclonal antibodies: a disproportionality analysis in the food and drug administration’s adverse event reporting system (FAERS)
  Pera, Victor & Brusselle, Guy & Riemann, Sebastian & Kors, Jan & van Mulligen, Erik M. & Parry, Rowan & Wilde, Marcel & Rijnbeek, Peter & Verhamme, Katia. (2023). Frontiers in Pharmacology. 14. 10.3389/fphar.2023.1276340.
  
  
• Supporting Pharmacovigilance Signal Validation and Prioritization with Analyses of Routinely Collected Health Data: Lessons Learned from an EHDEN Network Study
  Gauffin, Oskar & Brand, Judith & Vidlin, Sara & Sartori, Daniele & Asikainen, Suvi & Català, Martí & Chalabi, Etir & Dedman, Daniel & Danilovic, Ana & Duarte-Salles, Talita & Morales, Maria & Hiltunen, Saara & Jödicke, Annika & Lazarevic, Milan & Mayer, Miguel Angel & Miladinovic, Jelena & Mitchell, Joseph & Pistillo, Andrea & Ramírez-Anguita, Juan & Norén, Niklas & ... & Wilde, Marcel. (2023). Drug Safety. 46. 10.1007/s40264-023-01353-w.
  
  
• Drug utilization analysis of osteoporosis medications in seven European electronic health databases
  Tan, Eng & Robinson, Danielle & Jödicke, Annika & Mosseveld, Mees & Bødkergaard, Katrine & Reyes, Carlen & Moayyeri, Alireza & Voß, Annemarie & Maconi, Ettore & Lapi, Francesco & Reinold, Jonas & Verhamme, Katia & Pedersen, Lars & Braitmaier, Malte & Wilde, Marcel & Ruiz, Marc & Aragón, María & Bosco, P. & Lassalle, Régis & Sanchez, Maria. (2023). Osteoporosis International. 34. 10.1007/s00198-023-06837-0.
  
  
• Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data. Arthritis Research & Therapy
  Kamps, Anne & Runhaar, Jos & Ridder, Maria & Wilde, Marcel & Lei, Johan & Zhang, Weiya & Prieto-Alhambra, Daniel & Englund, Martin & Schepper, Evelien & Bierma-Zeinstra, Sita. (2023). 25. 10.1186/s13075-023-03086-8.
  
  
• Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study
  Voss, Erica & Shoaibi, Azza & Lai, Lana & Blacketer, Clair & Alshammari, Thamir & Makadia, Rupa & Haynes, Kevin & Sena, Anthony & Rao, Gowtham & van Sandijk, Sebastiaan & Fraboulet, Clement & Boyer, Laurent & Carrour, Tanguy & Horban, Scott & Morales, Daniel & Roldán, Jordi & Ramírez-Anguita, Juan & Mayer, Miguel Angel & Wilde, Marcel & Ryan, Patrick. (2023). eClinicalMedicine. 58. 101932. 10.1016/j.eclinm.2023.101932.
  
  
• Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands. Osteoarthritis and Cartilage
  Kamps, Anne & Runhaar, Jos & Ridder, Maria & Wilde, Marcel & Lei, Johan & Zhang, Weiya & Prieto-Alhambra, Daniel & Englund, Martin & Schepper, Evelien & Bierma-Zeinstra, Sita. (2022). 31. 10.1016/j.joca.2022.12.003.
  
  
• Epidemiology of chronic inflammatory demyelinating polyradiculoneuropathy in The Netherlands.
  Broers MC, de Wilde M, Lingsma HF, van der Lei J, Verhamme KMC, Jacobs BC.J Peripher Nerv Syst. 2022 Sep;27(3):182-188. doi: 10.1111/jns.12502. Epub 2022 May 29.PMID: 35567759
  
  
• Data Resource Profile: The Integrated Primary Care Information (IPCI) database, The Netherlands.
  de Ridder MAJ, de Wilde M, de Ben C, Leyba AR, Mosseveld BMT, Verhamme KMC, van der Lei J, Rijnbeek PR.Int J Epidemiol. 2022 Feb 19:dyac026. doi: 10.1093/ije/dyac026. Online ahead of print.PMID: 35182144 No abstract available.
  
  
• Incidence and Prevalence of Knee Osteoarthritis Using Codified and Narrative Data From Electronic Health Records: A Population-Based Study.
  Arslan IG, Damen J, de Wilde M, van den Driest JJ, Bindels PJE, van der Lei J, Schiphof D, Bierma-Zeinstra SMA.Arthritis Care Res (Hoboken). 2022 Jun;74(6):937-944. doi: 10.1002/acr.24861. Epub 2022 Apr 9.PMID: 35040591 Free PMC article.
  
  
• Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study.
  Lane JCE, Weaver J, Kostka K, Duarte-Salles T, Abrahao MTF, Alghoul H, Alser O, Alshammari TM, Areia C, Biedermann P, Banda JM, Burn E, Casajust P, Fister K, Hardin J, Hester L, Hripcsak G, Kaas-Hansen BS, Khosla S, Kolovos S, Lynch KE, Makadia R, Mehta PP, Morales DR, Morgan-Stewart H, Mosseveld M, Newby D, Nyberg F, Ostropolets A, Woong Park R, Prats-Uribe A, Rao GA, Reich C, Rijnbeek P, Sena AG, Shoaibi A, Spotnitz M, Subbian V, Suchard MA, Vizcaya D, Wen H, Wilde M, Xie J, You SC, Zhang L, Lovestone S, Ryan P, Prieto-Alhambra D; OHDSI-COVID-19 consortium.Rheumatology (Oxford). 2021 Jul 1;60(7):3222-3234. doi: 10.1093/rheumatology/keaa771.PMID: 33367863 Free PMC article.
  
  
• Antidepressant and anticonvulsant prescription rates in patients with osteoarthritis: a population-based cohort study.
  van den Driest JJ, Schiphof D, de Wilde M, Bindels PJE, van der Lei J, Bierma-Zeinstra SMA.Rheumatology (Oxford). 2021 May 14;60(5):2206-2216. doi: 10.1093/rheumatology/keaa544.PMID: 33175150 Free PMC article.
  
  
• Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study.
  Lane JCE, Weaver J, Kostka K, Duarte-Salles T, Abrahao MTF, Alghoul H, Alser O, Alshammari TM, Biedermann P, Banda JM, Burn E, Casajust P, Conover MM, Culhane AC, Davydov A, DuVall SL, Dymshyts D, Fernandez-Bertolin S, Fišter K, Hardin J, Hester L, Hripcsak G, Kaas-Hansen BS, Kent S, Khosla S, Kolovos S, Lambert CG, van der Lei J, Lynch KE, Makadia R, Margulis AV, Matheny ME, Mehta P, Morales DR, Morgan-Stewart H, Mosseveld M, Newby D, Nyberg F, Ostropolets A, Park RW, Prats-Uribe A, Rao GA, Reich C, Reps J, Rijnbeek P, Sathappan SMK, Schuemie M, Seager S, Sena AG, Shoaibi A, Spotnitz M, Suchard MA, Torre CO, Vizcaya D, Wen H, de Wilde M, Xie J, You SC, Zhang L, Zhuk O, Ryan P, Prieto-Alhambra D; OHDSI-COVID-19 consortium.Lancet Rheumatol. 2020 Nov;2(11):e698-e711. doi: 10.1016/S2665-9913(20)30276-9. Epub 2020 Aug 21.PMID: 32864627 Free PMC article.
  
  
• Opioid prescriptions in patients with osteoarthritis: a population-based cohort study.
  van den Driest JJ, Schiphof D, de Wilde M, Bindels PJE, van der Lei J, Bierma-Zeinstra SMA.Rheumatology (Oxford). 2020 Sep 1;59(9):2462-2470. doi: 10.1093/rheumatology/kez646.PMID: 31960046 Free PMC article.
  
  
• The association of vascular disorders with incident dementia in different age groups.
  Legdeur N, van der Lee SJ, de Wilde M, van der Lei J, Muller M, Maier AB, Visser PJ.Alzheimers Res Ther. 2019 May 17;11(1):47. doi: 10.1186/s13195-019-0496-x.PMID: 31097030 Free PMC article.
  
  
• Identifying Data Elements to Measure Frailty in a Dutch Nationwide Electronic Medical Record Database for Use in Postmarketing Safety Evaluation: An Exploratory Study.
  Sultana J, Leal I, de Wilde M, de Ridder M, van der Lei J, Sturkenboom M, Trifiro' G.Drug Saf. 2019 Jun;42(6):713-719. doi: 10.1007/s40264-018-00785-z.PMID: 30617499
  
  
• Translation of clinical prediction rules for febrile children to primary care practice: an observational cohort study.
  van Ierland Y, Elshout G, Berger MY, Vergouwe Y, de Wilde M, van der Lei J, Mol HA, Oostenbrink R.Br J Gen Pract. 2015 Apr;65(633):e224-33. doi: 10.3399/bjgp15X684373.PMID: 25824182 Free PMC article.
  
  
• Alarming signs and symptoms in febrile children in primary care: an observational cohort study in The Netherlands.
  Elshout G, van Ierland Y, Bohnen AM, de Wilde M, Moll HA, Oostenbrink R, Berger MY.PLoS One. 2014 Feb 19;9(2):e88114. doi: 10.1371/journal.pone.0088114. eCollection 2014.PMID: 24586305 Free PMC article.
  
  
• Alarm signs and antibiotic prescription in febrile children in primary care: an observational cohort study.
  Elshout G, van Ierland Y, Bohnen AM, de Wilde M, Oostenbrink R, Moll HA, Berger MY.Br J Gen Pract. 2013 Jul;63(612):e437-44. doi: 10.3399/bjgp13X669158.PMID: 23834880 Free PMC article. Review.
  
  
• Is OpenSDE an alternative for dedicated medical research databases? An example in coronary surgery.
  Venema AC, van Ginneken AM, de Wilde M, Bogers AJ.BMC Med Inform Decis Mak. 2007 Oct 22;7:31. doi: 10.1186/1472-6947-7-31.PMID: 17953759 Free PMC article.
  
  
• Generic computer-based questionnaires: an extension to OpenSDE.
  van Ginneken AM, de Wilde M, Blok C.Stud Health Technol Inform. 2004;107(Pt 1):688-92.PMID: 15360901
  
  
• OpenSDE: Row modeling applied to generic structured data entry.
  Los RK, van Ginneken AM, de Wilde M, van der Lei J.J Am Med Inform Assoc. 2004 Mar-Apr;11(2):162-5. doi: 10.1197/jamia.M1375. Epub 2003 Dec 7.PMID: 14662800 Free PMC article.